Sorafenib intermediate CAS 327-78-6
Identification
CAS Number
327-78-6
Name
4-Chloro-3-(trifluoromethyl)phenyl isocyanate
Synonyms
Intermediate of Sorafenib
Molecular Structure
SMILES
FC(F)(F)c1cc(N=C=O)ccc1Cl
StdInChI
InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H
StdInChIKey
NBJZEUQTGLSUOB-UHFFFAOYSA-N
Molecular Formula
C8H3ClF3NO
Molecular Weight
221.56
MDL Number
MFCD00013874
Properties
Appearance
White to off-white crystal
Refractive Index
1.487
Boiling Point
86-90 °C/14 mmHg(lit.)
Melting Point
40-42 °C(lit.)
Flash Point
99 °C
Density
1.4 g/mL
Safety Data
Symbol
GHS07
Signal Word
Warning
Hazard Statements
Precautionary Statements
Personal Protective Equipment
dust mask type(N95) US, Eye Shields, Gloves
Hazard Codes (Europe)
Risk Statements (Europe)
Safety Statements (Europe)
7-26-27-37/39
RIDADR
UN 2206 6.1/PG 3
WGK Germany
3
Specifications and Other Information of Our Sorafenib intermediate CAS 327-78-6
Purity
99%min(By HPLC)
Identification Method
HNMR, HPLC
Known Application
The intermediate of sorafenib (CAS 327-78-6), which is a drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma) and advanced primary liver cancer (hepatocellular carcinoma)
Productivity
1000kg/month
Watson-Int Link
http://watson-int.com/Intermediate-of-sorafenib_CAS_327-78-6.html