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OICR-9429 CAS 1801787-56-3

OICR-9429 CAS 1801787-56-3

In Intermediates, Pharmaceutical Chemicals, Products

Name

OICR-9429

Synonyms

N-(4-(4-methylpiperazin-1-yl)-3′-(morpholinomethyl)-[1,1′-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

Molecular Formula

C29H32F3N5O3

Molecular Weight

555.59

CAS Number (Or Watson Number for Non-CAS Products)

1801787-56-3

EINECS

Specs/Standards

98%min

Use

OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . target: Wdr5 IC 50: 5 uM In vitro: OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5. reduce the viability of primary human AML cells with N-terminal C/EBP¦Á mutations by about 50% (mean value, n = 8) at 5 ¦ÌM In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg.

Sales Link

This product is exclusively sold through our sales company Watson International Ltd and please refer to the link below for inquiries
http://watson-int.com/OICR-9429-cas-1801787-56-3/