Lercanidipine HCL CAS 132866-11-6

Identification

CAS Number

132866-11-6

Name

Lercanidipine HCL

Synonyms

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride
Zanidip
Lerdip

Molecular Structure

Structure of Lercanidipine HCL CAS 132866-11-6

SMILES

Cl.[O-][N+](=O)c1cccc(c1)C4C(=C(/NC(=C4C(=O)OC(C)(C)CN(CCC(c2ccccc2)c3ccccc3)C)C)C)C(=O)OC

StdInChI

InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H

StdInChIKey

WMFYOYKPJLRMJI-UHFFFAOYSA-N

Molecular Formula

C36H41N3O6.HCL

Molecular Weight

648.19

Properties

Appearance

Light yellow to yellow powder

Melting Point

185-190°C

Boiling Point

712.5 °C at 760 mmHg

Flash Point

384.7 °C

Safety Data

Symbol

skull-jpgGHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Personal Protective Equipment

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes (Europe)

T

Risk Statements (Europe)

25

Safety Statements (Europe)

36/37-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

3

Specifications and Other Information of Our Lercanidipine HCL CAS 132866-11-6

Purity

99.5% min

Single Impurity

0.07% max

Loss on Drying

0.5% max

Heavy Metals

20 ppm max

Known Actions

It is a L-type vascular channel antagonist; L-type cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine.

Known Application

It is also called Lercanidipine or Zanidip, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. This lowers the blood pressure and allows the heart to work more efficiently.

Productivity

500kg/month

Storage

2-8°C away from light, keep dry.

Watson-Int Link

ttp://watson-int.com/Lercanidipine-HCL_CAS_132866-11-6.html