0

Ciclesonide CAS 126544-47-6 (141845-82-1)

In APIs

Identification

CAS Number

126544-47-6 (141845-82-1)

Name

Ciclesonide

Synonyms

(R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate
2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-Cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2′,1′:4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl 2-m ethylpropanoate
ethylpropanoat
ethylpropanoate
Alvesco
Omnair
Omnaris
Osonide

Molecular Structure

Structue of Ciclesonide CAS 126544-47-6(141845-82-1)

SMILES

O=C(OCC(=O)[[email protected]]25O[[email protected]@H](O[[email protected]@H]5C[[email protected]]1[[email protected]]4[[email protected]]([[email protected]@H](O)C[[email protected]@]12C)[[email protected]]/3(/C=CC(=O)C=C3CC4)C)C6CCCCC6)C(C)C

StdInChI

InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1

StdInChIKey

LUKZNWIVRBCLON-GXOBDPJESA-N

Molecular Formula

C32H44O7

Molecular Weight

540.69

Properties

Appearance

Off-white to white crystalline powder

Flash Point

209.975 °C

Boiling Point

664.979 °C at 760 mmHg

Density

1.237 g/ml

Safety Data

Personal Protective Equipment

Eyeshields, Gloves

Specifications and Other Information of Our Ciclesonide CAS 126544-47-6 (141845-82-1)

Purity

99.0%min(HPLC)

Isomer

0.5% max(Higher Isomer percentage may affect the activity of ingredient)

Single Impurity

0.1% max

Known Application

Ciclesonide(126544-47-6 (141845-82-1)) is a glucocorticoid used to treat asthma and allergic rhinitis. It is marketed under the brand name Alvesco for asthma and Omnaris/Omniair for hay fever in the US and Canada. Phase 3 trials for the hay fever indication outside the US are ongoing.The drug was approved for adults and children 12 and over by FDA in October 2006.Side effects of the medication include headache, nosebleeds, and inflammation of the nose and throat linings.

More Information of Final Medicine

The consumption of Ciclesonide active ingredient is 160μg/time, and 1 time/day.

Productivity

kg scale

Watson-Int Link

http://watson-int.com/Ciclesonide_CAS_126544-47-6(141845-82-1).html