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MK-4101 CAS 935273-79-3

MK-4101 CAS 935273-79-3

In Intermediates, Pharmaceutical Chemicals, Products

Name

MK-4101

Synonyms

5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole

Molecular Formula

C24H24F5N5O

Molecular Weight

493.47

CAS Number (Or Watson Number for Non-CAS Products)

935273-79-3

EINECS

Specs/Standards

98%min

Use

MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma. target:SMO In vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice. In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induce deregulation of cell cycle and block of DNA replication in tumors.

Sales Link

This product is exclusively sold through our sales company Watson International Ltd and please refer to the link below for inquiries
http://watson-int.com/MK-4101-cas-935273-79-3/