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MK-8776 CAS 891494-63-6

MK-8776 CAS 891494-63-6

In Intermediates, Pharmaceutical Chemicals, Products

Name

MK-8776

Synonyms

6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine;MK-8776 (SCH 900776);SCH 900776 (MK-8776);SCH900776(R);6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((R)-piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;SCH 900776

Molecular Formula

C15H18BrN7

Molecular Weight

376.25

CAS Number (Or Watson Number for Non-CAS Products)

891494-63-6

EINECS

Specs/Standards

99%min

Use

MK-8776 is an ineffective inhibitor of Chk2 and CDK2 with IC50 of 1.5 ¦ÌM and 0.16 ¦ÌM, respectively. SCH 900776 had no significant inhibitory effect on cytochrome P450 human liver microsomal subtypes 1A2, 2C9, 2C19, 2D6, and 3A4. After exposure to hydroxyurea for 24 hours, SCH 900776 induced DNA replication in a dose-dependent manner. SCH 900776 enhances the response of gamma-H2AX to hydroxyurea, 5-fluorouracil, and arachidoside. In association with the anti-metabolite, SCH 900776 induced the accumulation of gamma-H2AX within 2 hours, indicating that the replication was disintegrated and the double-stranded DNA was broken. In addition, SCH 900776 inhibits the accumulation of autocrine phosphorylation of Chk1 pS296 in a dose-dependent manner. Proliferation of WS1 cells was exposed to SCH 900776, which was associated with rapid, dose-dependent aggregation of Chk1 pS345, indicating that the circulating cycle of normal cells induced Chk1 pS345 was part of an ineffective cycle after exposure to SCH 900776, which may be mediated by AT- DNA-PK drive.

Sales Link

This product is exclusively sold through our sales company Watson International Ltd and please refer to the link below for inquiries
http://watson-int.com/MK-8776-cas-891494-63-6/