1-Ferrocenylethanol CAS 1277-49-2
Identification
CAS Number
1277-49-2
Name
1-Ferrocenylethanol
Synonyms
α-Ferrocenylethanol
α-Methylferrocenemethanol
(1-Hydroxyethyl)ferrocene
NSC 162110
Molecular Structure
SMILES
CC(C1=CC=CC1[Fe]C2C=CC=C2)O
StdInChI
InChI=1S/C7H9O.C5H5.Fe/c1-6(8)7-4-2-3-5-7;1-2-4-5-3-1;/h2-6,8H,1H3;1-5H;
SydInChIKey
NJPGTUIMEAOISI-UHFFFAOYSA-N
Molecular Formula
C12H14FeO
Molecular Weight
230.08
MDL Number
MFCD00013752
Properties
Appearance
Yellow or off-yellow powder
Melting Point
76-79 °C(lit.)
Safety Data
Symbol
GHS07
Signal Word
Warning
Hazard Statements
Precautionary Statements
Personal Protective Equipment
dust mask type(N95) US, Eye Shields, Gloves
Hazard Codes (Europe)
Risk Statements (Europe)
Safety Statements (Europe)
26-36
WGK Germany
3
RTECS
LK0730000
MSDS Download
MSDS of 1-Ferrocenylethanol CAS 1277-49-2
Specifications and Other Information of Our 1-Ferrocenylethanol CAS 1277-49-2
Purity
98%min(By HPLC)
Identification Method
HNMR, HPLC
Known Actions
- Ligand in titanium-catalyzed intermolecular hydroamination of terminal alkynes (Markovnikov vs. anti-Markovnikov addition)
Reactant for
- Single-electron transfer living radical polymerization reactions
- Preparation of ferrocene-modified thiopyrimidines as anticancer agents
- Preparation of rersible addition-fragmentation chain transfer (RAFT) agent for RAFT polymerization of styrene
Known Application
Ferrocenyl derivative exhibits physiological activity of anti-malarial, anti-tumor, bactericidal, anti-inflammatory, treatment of anemia, inhibition of enzymatic activity and so on by virtue of its unique structure and diverse properties,
- Good stability, low toxicity;
- Aromatic, easy for substitution reaction and modification; Hydrophobic, attacking a variety of enzymes in cells, DNA, RNA by going through cell membrane;
- Strong selectivity by its thickness of the sandwich structure, which can stop it close to the activity site of enzymes; Redox reversibility, which enable it to involve in metabolism by enzymes. So nowadays, ferrocenyl derivative has wide applications to biological and medical fields such as ferrocene-modified beta-lactam.
Productivity
500kg/month
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