Travoprost CAS 157283-68-6

Travoprost CAS 157283-68-6

Identification

CAS Number

157283-68-6

Name

Travoprost

Synonyms

(+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2
15(S)-FLU-IPR
15(S)-FLUPROSTENOL ISOPROPYL ESTER
(+)-9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
9ALPHA,11ALPHA,15S-TRIHYDROXY-16(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
(+)-FLUPROSTENOL ISOPROPYL ESTER
FLUPROSTENOL ISOPROPYL ESTER
FLU-IPR
1-methylethyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
Travatan
Travatan Z

Molecular Structure

Structure of Travoprost CAS 157283-68-6

SMILES

FC(F)(F)c2cc(OC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C\C=C/CCCC(=O)OC(C)C)ccc2

StdInChI

InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1

StdInChIKey

MKPLKVHSHYCHOC-AHTXBMBWSA-N

Molecular Formula

C26H35F3O6

Molecular Weight

500.5477

Properties

Appearance

Light yellow to almost colourless oil

Flash Point

307.5°C

Boiling Point

584.8°C at 760 mmHg

Density

1.245g/ml

Refractive Index

1.547

Safety Data

Symbol

flame-jpgexclamation-mark-jpgGHS02, GHS07

Risk Statements (Europe)

11-36/37/38

Safety Statements (Europe)

16-26-36

Specifications and Other Information of Our Travoprost CAS 157283-68-6

Standard

USP34

Identification Methods

HPLC, TLC

Assay

96.0%-102%

Solubility

Soluble in chloroform,ethyl acetate, acetone, practically insoluble in water

Specific Rotation

+52°~+58°,(C=1 CH2Cl2)

Water

≤1.0%

Related Compounds

Epoxide derivative ≤0.40%
15-epi Diastereomer ≤0.1%
5,6-trans Isomer ≤3.5%
15-Keto derivative ≤0.3%
Any other impurities ≤0.1%
Total other impurity ≤1.0%

Related Solvents

Isopropanol ≤0.5%
Ethyl acetate ≤0.25%
n-Hexane ≤0.029%
Ethanol ≤0.5%

Description

Travoprost is a clear,colorless to slightly yellow oil that is very soluble inacetonitrile, methanoloctanoland chloroform.It is practically insoluble in water.

Adding proportion for reference

Travoprost is asynthetic prostaglandin F2a analog. Travoprost ophthalmic solution 0.003% is supplied as sterile,isotonic,buffered aqueous solution of travoprost with a pH of approximately 6.8 and an osmolalityof approximately 290 mOsmol/kg.

Travoprost ophthalmic solution 0.003% contains Active:
Iravoprost 0.03 mg/mL;
Preservative: polyquatemium-1- 0.0Img/mL;
Inactives: boric acid, mannitol, polyoxyethylene 40 hydrogenated castor oil, propylene glycol, sodium chloride, sodium hydroxide and or hydrochloric acid(to adjust pH) andpurfied water.

Known Application

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.

Package

Plastic bag inside and paper drum outside.

Productivity

kg scale/month

Storage

Glass bottle, 2-8°C for shipment and 0 ℃ for long time storage

General View of Documents

Travoprost CAS 157283-68-6 NMR1

Travoprost CAS 157283-68-6 NMR1


Travoprost CAS 157283-68-6 NMR2

Travoprost CAS 157283-68-6 NMR2


Travoprost CAS 157283-68-6 NMR3

Travoprost CAS 157283-68-6 NMR3

Available Impurities

Impurity 1
Name: Epoxide Derivative
Chemical Name: (5Z)-(9S,11R,15S)-9,11,15-Trihydroxy-13,14-epoxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure of 13,14 Epoxy derivative of Travoprost

Structure of 13,14 Epoxy derivative of Travoprost

Impurity 2
Name: 15-epi Diastereomer
Chemical Name: (5Z,13E)-(9S,11R,15S)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure of 15-epi Diastereomer

Structure of 15-epi Diastereomer

Impurity 3
Name: 5,6-trans Isomer
Chemical Name: (5E,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure of 5,6-trans Isomer

Structure of 5,6-trans Isomer

Impurity 4
Name: 15-keto derivative
Full Name: (5Z,13E)-(9S,11R)-9,11-Dihydroxy-15-oxo-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
CAS: 404830-45-1
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure of 15-keto Travoprost CAS 404830-45-1

Structure of 15-keto Travoprost CAS 404830-45-1

Links

This product is developed by our sub R&D company Caming Pharmaceutical Ltd, and please click the link below for details.
http://caming.com/travoprost-cas-157283-68-6/

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://watson-int.com/travoprost-cas-157283-68-6-2/