Sodium levofolinate CAS 1141892-29-6

Sodium levofolinate CAS 1141892-29-6

Identification

CAS Number

1141892-29-6

Name

Sodium levofolinate

Synonyms

(2S)-2-{[4-({[(6S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-ptéridinyl]méthyl}amino)benzoyl]amino}pentanedioate de disodium [French] [ACD/IUPAC Name]
1141892-29-6 [RN]
Dinatrium-(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentandioat [German] [ACD/IUPAC Name]
Disodium (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]amino}pentanedioate [ACD/IUPAC Name]
Disodium (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]amino}pentanedioate
LEVOLEUCOVORIN DISODIUM
L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, sodium salt (1:2) [ACD/Index Name]
163254-40-8 [RN]
Disodium folinate
LEUCOVORIN SODIUM
UNII-4MXU9LJS4Q

SMILES

c1cc(ccc1C(=O)N[[email protected]@H](CCC(=O)[O-])C(=O)[O-])NC[[email protected]]2CNc3c(c(=O)nc([nH]3)N)N2C=O.[Na+].[Na+]

StdInChI

InChI=1S/C20H23N7O7.2Na/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;/q;2*+1/p-2/t12-,13-;;/m0../s1

StdInChIKey

FSDMNNPYPVJNAT-NJHZPMQHSA-L

Molecular Formula

C20H21N7Na2O7

Molecular Weight

517.403

Properties

Appearance

White to yellow amorphous or crystalline

Safety Data

RIDADR 

Not dangerous goods

WGK Germany

3

Specifications and Other Information of Our Sodium levofolinate CAS 1141892-29-6

Identification Methods

HNMR, HPLC

Purity

97% min

Assay(on anhydrous basis)

97.0-102.0%

Heavy Metals

≤50ppm

Water

≤17%

Related substances

Any other impurity

≤2.0%

Total Impurities

≤3.0%

D-lsorner

≤1.0%

Shelf Life

1 year

Storage

Under room temperature away from light

Known Application

It can be used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.); it can also be used for the treatment of megaloblastic anemia caused by folate deficiency and the treatment of advanced colon and rectal cancer.

Watson International Ltd

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