Pomalidomide CAS 19171-19-8

Pomalidomide CAS 19171-19-8

  • Identification
  • Properties
  • Safety Data
  • Specifications & Other Information
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  • Identification

    CAS Number

    19171-19-8

    Name

    Pomalidomide

    Synonyms

    1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
    19171-19-8 [RN]
    1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)- [ACD/Index Name]
    3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
    4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindol-1,3(2H)-dion [German] [ACD/IUPAC Name]
    4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione [ACD/IUPAC Name]
    4-Amino-2-(2,6-dioxo-3-pipéridinyl)-1H-isoindole-1,3(2H)-dione [French] [ACD/IUPAC Name]
    4-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
    4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
    Actimid
    D2UX06XLB5
    MFCD12756407 [MDL number]
    pomalidomida [Spanish] [INN]
    pomalidomide [French] [INN]
    Pomalidomide [INN] [USAN] [Wiki]
    POMALIDOMIDE, (R)-
    POMALIDOMIDE, (S)-
    pomalidomidum [Latin] [INN]
    Pomalyst [Trade name]
    UNII:D2UX06XLB5
    (R)-pomalidomide
    [19171-19-8] [RN]
    1377838-49-7 [RN]
    1H-Indol-7-ylmethanol [ACD/IUPAC Name]
    202271-89-4 [RN]
    202271-90-7 [RN]
    2EE4M42K6G
    3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
    443912-23-0 [RN]
    443919-33-3 [RN]
    4-amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
    4-Amino-2-(2,6-dioxo-3-piperidyl) isoindoline -1,3-dione
    4-amino-2-(2,6-dioxo-3-piperidyl)isoindole-1,3-dione
    4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
    4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
    4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
    4-Amino-2-(2,6-dioxo-piperidin-3-yl)-isoindole-1,3-dione
    4-AMINO-2-(2,6-DIOXO-PIPERIDIN-3-YL)ISOINDOLE-1,3-DIONE
    4-Aminothalidomide
    Actimid,4-Aminothalidomide,CC 4047
    CC4047
    CC-4047;Actimid;CC4047;CC 4047
    CC-4047|IMID-3|Imnovid®|Pomalyst®
    D08976
    DB08910
    IMID-3
    Imnovid
    Imnovid (trade name)
    Imnovid®
    NR3397905
    Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-
    pomalidomida
    Pomalidomide (CC-4047)
    Pomalidomide (JAN/USAN/INN)
    pomalidomide(cc-4047,actimid)
    Pomalidomide-d5
    pomalidomidum
    Pomalyst (TN)
    Pomalyst®
    помалидомид [Russian]
    بوماليدوميد [Arabic]
    泊马度胺 [Chinese]

    SMILES

    c1cc2c(c(c1)N)C(=O)N(C2=O)C3CCC(=O)NC3=O

    StdInChI

    InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

    StdInChIKey

    UVSMNLNDYGZFPF-UHFFFAOYSA-N

    Molecular Formula

    C13H11N3O4

    Molecular Weight

    273.24

    MDL Number

    MFCD12756407

    Properties

    Appearance

    White powder

    Safety Data

    RIDADR 

    NONH for all modes of transport

    Specifications and Other Information of Our Pomalidomide CAS 19171-19-8

    Identification Methods

    HNMR, HPLC

    Purity

    95% min

    Storage

    Store at 2-8℃ for long time.

    Features

    Substrate Proteins: The primary ligands for E3 ligases are substrate proteins that need to be ubiquitinated for degradation or regulation. These substrate proteins can vary widely depending on the specific E3 ligase and the cellular process it regulates.

    Ubiquitin: In the ubiquitination process, ubiquitin itself acts as a ligand. It forms a thioester bond with the active site cysteine of the E3 ligase before being transferred to the substrate protein.

    Adaptor Proteins: Some E3 ligases require adaptor proteins to facilitate substrate recognition and ubiquitination. These adaptor proteins can also act as ligands for the E3 ligase.

    Small Molecules: In some cases, small molecules or chemical compounds can modulate the activity of E3 ligases by binding to them directly or affecting their interactions with other proteins.

    Post-translational Modifications (PTMs): PTMs of either the E3 ligase itself or its substrate proteins can also serve as ligands, regulating the ubiquitination process.

    Overall, the ligands for E3 ligases play crucial roles in substrate recognition, ubiquitin transfer, and the regulation of cellular processes.

    Known Application

    Substrate Recognition: Ligands facilitate the recognition of specific substrate proteins by E3 ligases. These ligands can be protein motifs, post-translational modifications (such as phosphorylation or acetylation), or adaptor proteins that bring substrates to the E3 ligase.

    Ubiquitination: Once a substrate is recognized, E3 ligases catalyze the transfer of ubiquitin molecules to the substrate protein. These ligands are crucial for facilitating the transfer of ubiquitin from the E2 ubiquitin-conjugating enzyme to the substrate.

    Regulation of Protein Stability: Ubiquitination mediated by E3 ligases marks substrate proteins for degradation by the proteasome. Ligands for E3 ligases thus regulate the stability of proteins in the cell by targeting them for degradation.

    Regulation of Protein Function: Ubiquitination can also regulate the activity, localization, or interaction partners of substrate proteins without leading to degradation. Ligands for E3 ligases are involved in this regulatory process by controlling the extent and site of ubiquitination.

    Cellular Signaling: Ubiquitination mediated by E3 ligases is involved in various cellular signaling pathways, including those regulating cell cycle progression, DNA repair, immune response, and apoptosis. Ligands for E3 ligases modulate these signaling pathways by targeting specific proteins for ubiquitination.

    Overall, ligands for E3 ligases are essential for substrate recognition, ubiquitination, and the regulation of protein stability and function, thereby influencing numerous cellular processes and signaling pathways.

    This product is developed by our R&D company Watson International Ltd (https://www.watson-int.com/).