PLB-1001 CAS 1440964-89-5

PLB-1001 CAS 1440964-89-5

Identification

CAS Number

1440964-89-5

Name

PLB-1001

Synonyms

1,2,4-Triazolo[4,3-b]pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-[difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl]- [ACD/Index Name]
6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-[difluor(6-fluor-2-methyl-2H-indazol-5-yl)methyl][1,2,4]triazolo[4,3-b]pyridazin [German] [ACD/IUPAC Name]
6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-[difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl][1,2,4]triazolo[4,3-b]pyridazine [ACD/IUPAC Name]
6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-[difluoro(6-fluoro-2-méthyl-2H-indazol-5-yl)méthyl][1,2,4]triazolo[4,3-b]pyridazine [French] [ACD/IUPAC Name]
1440964-89-5 [RN]
6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine
Bozitinib
Bozitinib (PLB-1001)

SMILES

CN1C=C2C=C(C(F)=CC2=N1)C(F)(F)C1=NN=C2C=CC(=NN21)C1=CN(N=C1)C1CC1

StdInChI

InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3

StdInChIKey

QHXLXUIZUCJRKV-UHFFFAOYSA-N

Molecular Formula

C20H15F3N8

Molecular Weight

424.382

Properties

Structure

Structure of PLB-1001 CAS 1440964-89-5
Structure of PLB-1001 CAS 1440964-89-5

Safety Data

Symbol

Signal Word

Warning

WGK Germany

3

MSDS Download

Specifications and Other Information of Our

Water

Loss on Drying

Residue on Ignition

Single Impurity

Total Impurities

Shelf Life

2 years

Storage

Store at -20°C and away from light

Known Applicationc

Bozitinib is a receptor tyrosine kinase inhibitor targeting the cell-mesenchymal-epithelial transition factor (c-MET), capable of inhibiting the proliferation of tumor cells with elevated c-MET expression. This drug can penetrate the blood-brain barrier and has been registered for 8 clinical trials domestically, with indications including non-small cell lung cancer (NSCLC), gliomas, and more.

General View of Documents

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