Levofolinic acid CAS 68538-85-2
Identification
CAS Number
68538-85-2
Name
Levofolinic acid
Synonyms
(6S)-5-formyltetrahydrofolic acid
68538-85-2 [RN]
Acide N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-ptéridinyl]méthyl}amino)benzoyl]-L-glutamique [French] [ACD/IUPAC Name]
Levoleucovorin
L-Folinic acid
L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]- [ACD/Index Name]
N-[4-({[(6S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]-L-glutamic acid [ACD/IUPAC Name]
N-[4-({[(6S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]-L-glutaminsäure [German] [ACD/IUPAC Name]
(2S)-2-[[[4-[[(6R)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]-oxomethyl]amino]pentanedioic acid
(2S)-2-[[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]-oxomethyl]amino]pentanedioic acid
(2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-keto-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]glutaric acid
(2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
(2S)-2-[[4-[[(6R)-2-amino-5-methanoyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]carbonylamino]pentanedioic acid
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-keto-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]glutaric acid
(2S)-2-[[4-[[(6S)-2-AMINO-5-FORMYL-4-OXO-1,6,7,8-TETRAHYDROPTERIDIN-6- YL]METHYLAMINO]BENZOYL]AMINO]PENTANEDIOIC ACID
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
(2S)-2-[[4-[[(6S)-2-amino-5-methanoyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]carbonylamino]pentanedioic acid
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
(6R,S)-5-Formyltetrahydrofolate
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid; (6S)-5-formyltetrahydrofolic acid; (6S)-Folinic acid; (6S)-Leucovorin; (S)-Leucovorin; Citrovorum factor; L-Folinic acid; Levofolene; Levofolinic acid; N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
(6S)-5-formyltetrahydrofolate
(6S)-5-HCO-H4folate
(6S)-Folinic acid
(6S)-Leucovorin
(S)-Leucovorin
[(6S)-5-formyl-5,6,7,8-tetrahydropteroyl]glutamate
10-formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
121451-09-0 [RN]
1492-18-8 [RN]
200-361-6 [EINECS]
58-05-9 [RN]
5-CHO-H4PteGlu1
5-FORMYL-5,6,7,8-TETRAHYDROFOLATE
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-FORMYL-6-HYDROFOLIC ACID
5-Formyltetrahydrofolate
5-formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
6R-Leucovorin
73951-54-9 [RN]
Antianemia factor
Apo-folic
Citrovorum factor
Citrovorum factor; Folinic acid; L-leucovorin; Levoleucovorin
FFO
folinate [Wiki]
folinic acid [INN] [Wiki]
Folinic acid calcium salt
Folinic acid-SF
Fusilev
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
Leucal
Leucovorin [USAN]
Levofolene
Levofolinic acid
L-Glutamic acid, N-(4-((((6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
L-Glutamic acid, N-(4-((((6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, (S)-
L-leucovorin
Mission Prenatal
Mittafol
MVC PLUS
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-D-Glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
n5-formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Nifolin
Novofolacid
Novo-folacid
N-Pteroyl-D-glutamic acid
Pteroyl-D-glutamate
Pteroyl-D-glutamic acid
Pteroylmonoglutamate
UNII-Q573I9DVLP
Uzel [Trade name]
Uzel (Trade name)
Uzel; Wellcovorin
Vitamin B11
VITAPED
Welcovorin
Wellcovorin [Trade name]
SMILES
c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC[[email protected]]2CNc3c(c(=O)nc([nH]3)N)N2C=O
StdInChI
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1
StdInChIKey
VVIAGPKUTFNRDU-STQMWFEESA-N
Molecular Formula
C20H23N7O7
Molecular Weight
473.439
EINECS
200-361-6
Properties
Appearance
Yellowish to yellow powder, odorless
Safety Data
RIDADR
NONH for all modes of transport
WGK Germany
3
Specifications and Other Information of Our Levofolinic acid CAS 68538-85-2
Identification Methods
HNMR, HPLC
Assay
97.0% – 102.0% on the anhydrous basis
Hygroscopicity
< 0.2%
Specific Optical Rotation
-11° to -16°
pH
3.5-4.5
Clarity
Solution should be clarity
Chlorides
≤ 0.5%
D-Leucovorin
≤ 0.5%
Heavy Metals
≤ 20ppm
Water
≤ 2.0%
Residue on Ignition
≤ 0.5%
Related Substances (I)
Impurity A
≤ 0.2%
Impurity E
≤ 0.2%
Impurity F
≤ 0.2%
Other single impurity
≤ 0.2%
Total Impurities
≤ 1.5%
Related Substances (II)
ZYG03≤ 0.6%
Ca
≤ 0.1%
Bacterial Endotoxin
< 1.0EU/mg
Microbial Limit
TAMC
≤ 1000cfu/g
TYMC
≤ 100cfu/g
E. Coli.
Absent in 1g
Shelf Life
2 years
Storage
Store at room temperature, sealed and away from light.
Known Application
Commonly used as impurity reference.
Links
This product is developed by our R&D company Watson International Ltd (https://www.watson-int.com/).