Halofuginon Lactate CAS 82186-71-8

Halofuginon Lactate CAS 82186-71-8

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

82186-71-8

Name

Halofuginon Lactate

Synonyms

2-Hydroxypropanoic acid – 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone (1:1) [ACD/IUPAC Name]
2-Hydroxypropansäure –7-brom-6-chlor-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-chinazolinon (1:1) [German] [ACD/IUPAC Name]
Acide 2-hydroxypropanoïque – 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-pipéridinyl]-2-oxopropyl}-4(3H)-quinazolinone (1:1) [French] [ACD/IUPAC Name]
Propanoic acid, 2-hydroxy-, compd. with 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone (1:1) [ACD/Index Name]
2-Hydroxypropanoic acid [ACD/IUPAC Name]
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one;2-hydroxypropanoic acid
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one and 2-hydroxypropanoic acid
82186-71-8 [RN]
Halofuginone lactate
Halofuginone lactate 100 ?g/mL in Acetonitrile
Halofuginone lactate 100 µg/mL in Acetonitrile – short expiry, for immediate use only

SMILES

CC(C(=O)O)O.c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)C[[email protected]]3[[email protected]@H](CCCN3)O

StdInChI

InChI=1S/C16H17BrClN3O3.C3H6O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;1-2(4)3(5)6/h5-6,8,14-15,19,23H,1-4,7H2;2,4H,1H3,(H,5,6)/t14-,15+;/m0./s1

StdInChIKey

GATQERNJKZPJNX-LDXVYITESA-N

Molecular Formula

C19H23BrClN3O6

Molecular Weight

504.76

Properties

Appearance

Off-white to white solid

Safety Data

WGK Germany

3

Specifications and Other Information of Our Halofuginon Lactate CAS 82186-71-8

Standard

Enterprise standard

Identification Methods

HPLC/HNMR

Purity

98%min

Package

According to customer requirements to packaging

Storage

Under the room temperature and away from light

Application

Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.
Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders.
Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.

Links

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/halofuginon-lactate-cas-82186-71-8/