AMG-650 CAS 2410796-79-9

AMG-650 CAS 2410796-79-9

Identification

CAS Number

2410796-79-9

Name

2410796-79-9

Synonyms

Validated by Experts, Validated by Users, Non-Validated, Removed by Users
2-(6-Azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluor-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-{[(2-hydroxyethyl)sulfonyl]amino}benzamid [German] [ACD/IUPAC Name]
2-(6-Azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-{[(2-hydroxyethyl)sulfonyl]amino}benzamide [ACD/IUPAC Name]
2-(6-Azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-pipéridinyl)-6-méthyl-4-pyrimidinyl]-4-{[(2-hydroxyéthyl)sulfonyl]amino}benzamide [French] [ACD/IUPAC Name]
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]- [ACD/Index Name]
2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-(2-hydroxyethylsulfonylamino)benzamide
2410796-79-9 [RN]
Sovilnesib

SMILES

Validated by Experts, Validated by Users, Non-Validated, Removed by Users
2-(6-Azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluor-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-{[(2-hydroxyethyl)sulfonyl]amino}benzamid [German] [ACD/IUPAC Name]
2-(6-Azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-{[(2-hydroxyethyl)sulfonyl]amino}benzamide [ACD/IUPAC Name]
2-(6-Azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-pipéridinyl)-6-méthyl-4-pyrimidinyl]-4-{[(2-hydroxyéthyl)sulfonyl]amino}benzamide [French] [ACD/IUPAC Name]
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]- [ACD/Index Name]
2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-(2-hydroxyethylsulfonylamino)benzamide
2410796-79-9 [RN]
Sovilnesib

StdInChI

CC1=CC(NC(=O)C2=CC=C(C=C2N2CCC3(CC3)CC2)NS(=O)(=O)CCO)=NC(=N1)N1CCC(F)(F)CC1

StdInChIKey

InChI=1S/C26H34F2N6O4S/c1-18-16-22(31-24(29-18)34-12-8-26(27,28)9-13-34)30-23(36)20-3-2-19(32-39(37,38)15-14-35)17-21(20)33-10-6-25(4-5-25)7-11-33/h2-3,16-17,32,35H,4-15H2,1H3,(H,29,30,31,36)

Molecular Formula

C26H34F2N6O4S

Molecular Weight

564.648

Properties

Appearance

Solid

Structure

structure of AMG-650 CAS 2410796-79-9
structure of AMG-650 CAS 2410796-79-9

Safety Data

Symbol

WGK Germany

3

MSDS Download

Specifications and Other Information of Our

Identification Methods

Shelf Life

2 years

Storage

Store at -20°C and away from light

Known Application

AMG 650 is a highly efficient and selective inhibitor targeting KIF18A, an overexpressed kinesin motor protein in human cancers. It selectively inhibits KIF18A MT-ATPase motor activity, displaying specificity towards various kinesin proteins. At concentrations affecting sensitive tumor cells, AMG 650 has minimal impact on the in vitro proliferation of human bone marrow mononuclear cells (>100 times). In vivo, AMG 650 exhibits low clearance, a long half-life, and favorable oral bioavailability. Additionally, when combined with the PARP inhibitor olaparib, AMG 650 enhances anticancer activity in tumor models with alterations in BRCA1 and CCNE1 compared to single-agent treatment.

General View of Documents

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